Defending women's champion Serena Williams is aiming to capture a record-tying 22nd major after being denied in the finals of the Australian Open and French Open by Angelique Kerber and Garbine Muguruza, respectively.
The American's run to the title last year was almost derailed by Britain's Heather Watson in the third round, where Williams was two points from losing before producing a 7-5 third-set triumph.
They could play in the third round again, although the more likely scenario is Williams tussling with Kristina Mladenovic -- who took their French Open clash last month to a second-set tiebreak before the 34-year-old prevailed 12-10.
Last year's beaten finalist Muguruza is attempting to avoid a hangover that often results for new grand slam winners when they compete in their next major, but the Spanish second seed was given a tricky first-round foe in 68th-ranked Italian Camila Giorgi.
German fourth seed Kerber was paired with British wildcard Laura Robson, whose promising career has taken a turn for the worse courtesy of longstanding wrist issues.
Robson, the Wimbledon junior champion in 2008, will be trying for a first victory over a top-30 opponent since Wimbledon in 2013.
While Muguruza and Kerber were drawn in the same half, Williams' semifinal rival is possibly Poland's third-ranked Agnieszka Radwanska, who she beat in the 2012 final.